Electrophilic oligodeoxynucleotide synthesis using dM-Dmoc for amino protection
نویسندگان
چکیده
منابع مشابه
Oligodeoxynucleotide synthesis using protecting groups and a linker cleavable under non-nucleophilic conditions
Oligodeoxynucleotides (ODNs) containing latent electrophilic groups can be highly useful in antisense drug development and many other applications such as chemical biology and medicine, where covalent cross-linking of ODNs with mRNA, protein and ODN is required. However, such ODN analogues cannot be synthesized using traditional technologies due to the strongly nucleophilic conditions used in t...
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The bromination of a series of cyclohexenyl substituted secondary amines 1a-i has been investigated using Br2, PHT and NBS. In the case of Br2 and NBS the secondary amines preferentially undergo N-bromination. In contrast, PHT cleanly affords the products of alkene dibromination. In the case ofBr2 the N-bromo species then give the products of alkene dibromination, albeit less efficiently. On su...
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The picolinoyl group has been used for amino protection in the case of all the three deoxynucieosides-dC, dA and dG , and good yie lds of N-protected nucleosides are obtained. This pyridine derivative along with another pyridine deri vat ive, viz. (a-pyridyl) methyl, an autocata lyti c phosphate protecting group, has been used successfull y in the sy nthes is o f two oligonucleotides, d(T ACGTT...
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ژورنال
عنوان ژورنال: Beilstein Journal of Organic Chemistry
سال: 2019
ISSN: 1860-5397
DOI: 10.3762/bjoc.15.108